History of Silver as an Antimicrobial
| 900's | In China, Emperor used only silver when eating "to prevent poisoning". |
| 1100's | In Europe, Vatican mandate to use silver goblet for the Eucharist |
| 1850's | Tea holders lined with silver foil |
| 1880 | Crede's prophylaxis for infant eye drops |
| 1920's | Over 3 million prescriptions written annually for silver-containing medications |
| 1960's | Silver compounds begin to be used in burn wards |
| 1970's | Silver based applications reemerge |
| 1990's | Commercialization of silver antimicrobials for plastics and coatings |
| 2000's | AgION used in "indwelling" medical device (catheter) |
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